Table 2.
Information on troponin measurement in included studies
| Study | Type of Tn assay | Manufacturer | Upper reference limit | Time of measurement | Proportion of patients with Tn measurement, no. measured/no. enrolled (%) | Frequency of Tn elevation, no. elevated/no. measured (%) |
|---|---|---|---|---|---|---|
| Arcari et al. | hs-TnT, hs-TnI | Roche, NA | 14 ng/L, 35 ng/L | Within 24 h of admission | 103/111 (92.8) | 39/103 (37.9) |
| Azoulay et al. | NA | NA | NA | On ICU admission | 343/379 (90.5) | 135/343 (39.4) |
| Barman et al. | hs-TnI | NA | 14 ng/L | On admission | 607/908 (66.9) | 150/607 (24.7) |
| Bhatla et al. | NA | NA | 0.010 ng/mL | On admission | 373/700 (53.3) | 82/373 (22.0) |
| Bhatraju et al. | NA | NA | 0.06 ng/mL | During first 3 days in ICU | 13/24 (54.2) | 2/13 (15.4) |
| Buckner et al. | NA | NA | 0.1 ng/mL | During hospitalisation | 67/105 (63.8) | 13/67 (19.4) |
| Cipriani et al. | hs-TnI | NA | 32 ng/L for men, 16 ng/L for women | On admission and during hospitalisation | 109/136 (80.1) | On admission, 41/109 (37.6); overall, 46/109 (42.2) |
| Du et al. | TnI | NA | 0.05 ng/mL | On admission | 179/179 (100) | 41/179 (22.9) |
| Ferguson et al. | NA | NA | 0.055 ng/mL | Within 24 h of admission | 45/72 (62.5) | 2/45 (4.4) |
| Franks et al. | TnI | Abbott | 0.03 ng/mL | On admission and during hospitalisation | On admission, 128/182 (70.3); overall, 143/182 (78.6) | On admission, 65/128 (50.8); overall, 80/143 (55.9) |
| Gottlieb et al. | NA | NA | 0.9 ng/mL | On admission | 390/1483 (26.3) | 87/390 (22.3) |
| Goyal et al. | NA | NA | 0.5 ng/mL | Within 48 h of admission | 246/393 (62.6) | 11/246 (4.5) |
| Harmouch et al. | TnI | NA | 0.05 ng/mL | On admission | 482/560 (86.1) | 97/482 (20.1) |
| He et al. | hs-TnI | NA | NA | During stay in ICU | 94/94 (100) | 35/94 (37.2) |
| Heberto et al. | hs-TnI | Beckman | 17.5 ng/L | On admission | 254/254 (100) | 64/254 (25.2) |
| Hu et al. | TnI | Siemens | 0.040 ng/mL | On admission | 323/323 (100) | 68/323 (21.1) |
| Huang et al. | TnT | NA | 0.13 ng/mL | On ICU admission | 60/60 (100) | 19/60 (31.7) |
| Karbalai et al. | hs-cTnI | NA | 26 ng/L for men, 11 ng/L for women | During hospitalisation | 386/386 (100) | 115/386 (29.8) |
| Lala et al. | TnI | Abbott | 0.03 ng/mL | Within 24 h of admission | 2736/3047 (89.8) | 1751/2736 (36.0) |
| Lazzeri et al. | TnT | NA | 0.028 ng/mL | On ICU admission | 28/28 (100) | 11/28 (39.3) |
| Li et al. | TnI | Beckman | 0.03 ng/mL | On admission | 82/82 (100) | 13/82 (15.9) |
| Li et al. | hs-TnI | Abbott | 34.2 ng/L | On admission | 2068/2699 (76.6) | 181/2068 (8.8) |
| Lombardi et al. | NA | NA | NA | Within 24 hours of admission | 614/614 (100) | 278/614 (45.3) |
| Lorente-Ros et al. | hs-TnI | NA | 14 ng/L | On admission | 707/707 (100) | 148/707 (20.9) |
| Lu et al. | TnI | NA | 0.4 ng/mL | During stay in ICU | 50/72 (69.4) | 36/50 (72.0) |
| Ma K, et al | TnI | NA | 0.034 ng/mL | During hospitalisation | 84/84 (100) | 9/84 (10.7) |
| Majure et al. | TnI, TnI, TnT, hs-TnT | Siemens, Siemens, Roche, Roche | 0.045 ng/mL, 0.056 ng/mL, 0.01 ng/mL, 19 ng/L | Within 48 hours of admission | 6247/11,159 (56.0) | 1821/6247 (29.1) |
| Mejía-Vilet et al. | TnI | NA | 0.020 ng/mL | On admission | 569/569 (100) | 86/569 (15.1) |
| Nguyen et al. | hs-TnI | NA | 22 ng/L | On admission | 340/356 (95.5) | 140/340 (41.2) |
| Nie et al. | hs-TnI | Abbott | 26.2 ng/L | During hospitalisation | NA | 103/311 (33.1) |
| Petrilli et al. | NA | NA | 0.1 ng/mL | On admission | 2510/2729 (92.0) | NA |
| Price-Haywood et al. | TnI | NA | 0.06 ng/mL | On admission | 1084/1382 (78.4) | 270/1084 (24.9) |
| Qi et al. | hs-TnT | Roche | 14 ng/L | On admission | 76/267 (28.5) | 3/76 (3.9) |
| Qin et al. | hs-TnI, TnI | Various | Various | On admission | 1462/6033 (24.2) | 95/1462 (6.5) |
| Raad et al. | hs-TnI | Beckman | 18 ng/L | On admission | 1020/1044 (97.7) | 390/1020 (38.2) |
| Shah et al. | TnI | NA | 0.05 ng/mL | During hospitalisation | 309/635 (48.7) | 116/309 (37.5) |
| Shah et al. | TnI | NA | 0.05 ng/mL | During hospitalisation | 14/26 (53.8) | 5/14 (35.7) |
| Shen et al. | TnI | Siemens | 0.040 ng/mL | On admission | 325/325 (100) | 80/325 (24.6) |
| Stefanini et al. | hs-TnI | Beckman | 19.6 ng/L | On admission | 397/397 (100) | 130/397 (32.7) |
| Szekely et al. | TnI | Abbott | 28 ng/L | On admission | 100/100 (100) | 20/100 (20) |
| Tan et al. | hs-TnI | Abbott | 26.2 ng/L | On admission | 115/115 (100) | 20/115 (17.4) |
| van den Heuvel et al. | hs-TnT | Roche | 14 ng/L | During hospitalisation | 47/51 (92.2) | 24/47 (51.1) |
| Wei et al. | hs-TnT | Roche | 14 ng/L | On admission | 101/103 (98.1) | 16/101 (15.8) |
| Woo et al. | hs-TnT, TnI | Roche, Siemens | 19 ng/L, 0.040 ng/mL | On admission | NA | NA |
| Xu et al. | TnI | NA | NA | On admission | 15/15 (100) | 1/15 (6.7) |
| Yang et al. | TnI | Siemens | 0.040 ng/mL | On admission | 463/463 (100) | 45/463 (9.7) |
| Yu et al. | hs-TnI, TnI | Abbott, NA | 28 ng/L, 0.3 ng/mL | During stay in ICU | 226/226 (100) | 61/226 (27.0) |
| Zeng et al. | TnI | NA | 0.026 ng/mL | On admission | 345/416 (82.9) | 29/345 (8.4) |
| Zhang et al. | hs-TnT | Roche | 14 ng/L | On admission | 135/135 (100) | 40/135 (29.6) |
| Zhao et al. | TnI | NA | 0.01 ng/mL | On admission | 88/91 (96.7) | 3/88 (3.4) |
| Zhou et al. | hs-TnI | Abbott | 28 ng/L | On admission | 145/191 (75.9) | 24/145 (16.6) |
Hs High-sensitivity, ICU Intensive care unit, NA Not available, Tn Troponin