Fig. 1.

Schematic representation of the interaction between tumor endothelial cells (TECs) and tumor associated macrophages (TAMs) under tumor hypoxia. The inflammation in tumor is primarily associated with the recruitment of tumor associated macrophages (TAMs) by chemotactic factors that are released from tumor cells or tumor endothelial cells (TECs). Thereafter, the recruited TAMs promote tumor angiogenesis by releasing pro-angiogenic factors. Based on the interaction between TECs and TAMs, the relationship between tumor angiogenesis and inflammation form a feed-forward manner