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. 2020 Nov 18;13:11883–11897. doi: 10.2147/OTT.S284192

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© 2020 Lu et al.

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Hsa-circ-0048117 could induce the polarization of M2 macrophages. (A) The agarose gel results showed that hsa-circ-0048117 was 86 bp in size. (B) The enzyme tolerance test after the RnaseR treatment to testify the circular structure of hsa-circ-0048117. (C) The gene information and structure of hsa-circ-0048117: located in chr19: 964832–968503, consisting exon6, exon7 and exon8, the spliced sequence length was 644bp and the splicing site was located at: CAGATA. (D) qRT-PCR: to evaluate the transfection efficiency of hsa-circ-0048117 over-expressed and inhibited by lentivirus and siRNA, respectively (***p<0.01). (E and F) Flow cytometry was used to detect the expression of M2 markers CD14 and CD206 (****p<0.001). (G) Western blot was used to examine the expression of CD14 and CD206 after hsa-circ-0048117 was upregulated and downregulated.