Table 2. Summary of Novel findings.
| MGI-BioVU Meta-Analysis | BioVU Replication Cohort | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lab | SNP | Chr:Pos | Allele 1 | Allele 2 | N | Beta | P-Value | N | Beta | P-Value | Replicated |
| AlkP | rs3843738 | 17:43739194 | A | G | 39,809 | 0.04 | 2.51E-08 | 22,920 | 0.01 | 3.58E-01 | No |
| AlkP | rs73004933 | 19:19675696 | T | C | 39,809 | 0.08 | 4.47E-09 | 22,730 | 0.05 | 7.14E-03 | Yes |
| ALT | rs112574791 | 8:145730221 | A | G | 40,116 | 0.18 | 3.02E-08 | 23,007 | 0.15 | 5.80E-04 | Yes |
| Amyl | rs1930212 | 1:104324819 | A | G | 10,368 | -0.25 | 1.48E-45 | 3,573 | -0.18 | 4.69E-09 | Yes |
| Amyl | rs8051363 | 16:75255217 | A | G | 10,368 | 0.10 | 1.07E-10 | 3,564 | 0.09 | 4.51E-04 | Yes |
| BasoRE | rs386785158 | 15:70744437 | T | C | 29,653 | 0.06 | 7.94E-13 | 16,191 | 0.04 | 2.10E-04 | Yes |
| Bili | rs855791 | 22:37462936 | A | G | 39,890 | 0.04 | 2.34E-08 | 22,918 | 0.04 | 1.00E-05 | Yes |
| BUN | rs10516957 | 4:95949206 | T | C | 45,922 | -0.06 | 1.35E-08 | 25,245 | 0.01 | 6.11E-01 | No |
| Ca | rs6727384 | 2:97400324 | A | G | 46,100 | -0.04 | 5.13E-10 | 25,200 | -0.05 | 2.06E-07 | Yes |
| Ca | rs2839899 | 9:80350999 | A | G | 46,100 | 0.04 | 6.76E-09 | 25,194 | 0.03 | 9.47E-03 | Yes |
| Cl | rs1030025 | 2:103105611 | A | T | 45,920 | 0.05 | 4.68E-10 | 25,204 | 0.02 | 9.16E-02 | No |
| FT4 | rs10122824 | 9:139109861 | T | G | 15,868 | 0.07 | 1.00E-09 | 9,721 | 0.07 | 7.28E-07 | Yes |
| Glucose | rs7607980 | 2:165551201 | T | C | 46,027 | -0.05 | 4.27E-09 | 25,312 | -0.04 | 2.09E-03 | Yes |
| Glucose | rs896854 | 8:95960511 | T | C | 46,027 | -0.04 | 1.55E-09 | 25,311 | 0.01 | 3.64E-01 | No |
| Glucose | rs9273364 | 6:32626302 | T | G | 46,027 | 0.05 | 2.63E-11 | 24,801 | 0.05 | 3.10E-06 | Yes |
| HgbA1C | rs3130628 | 6:31609272 | T | C | 17,407 | -0.08 | 1.23E-08 | 7,340 | 0.03 | 3.79E-02 | No |
| HCO3 (CO2) | rs1799913 | 11:18047255 | T | G | 45,932 | -0.04 | 5.89E-09 | 25,219 | -0.04 | 7.82E-07 | Yes |
| HCO3 (CO2) | rs77375846 | 2:103155075 | T | C | 45,932 | -0.10 | 9.33E-25 | 25,217 | -0.06 | 2.78E-05 | Yes |
| IGranRE | rs13284665 | 9:131513370 | A | G | 30,683 | 0.22 | 6.61E-74 | QC Fail | N/A | N/A | No |
| IGranAB | rs13284665 | 9:131513370 | A | G | 30,744 | 0.13 | 6.76E-35 | QC Fail | N/A | N/A | No |
| K | rs10039139 | 5:137164863 | T | G | 45,941 | 0.07 | 8.32E-16 | 25,211 | 0.06 | 1.83E-06 | Yes |
| Lipase | rs9377343 | 6:96512220 | A | G | 12,649 | -0.10 | 4.79E-14 | 5,564 | -0.08 | 3.60E-05 | Yes |
| Lipase | rs8051363 | 16:75255217 | A | G | 12,649 | 0.13 | 2.00E-20 | 5,549 | 0.07 | 8.39E-04 | Yes |
| MCHC | rs12352830 | 9:80041132 | C | G | 46,157 | -0.04 | 4.37E-08 | 26,243 | -0.04 | 5.77E-05 | Yes |
| MonoRE | rs117358683 | 12:44145965 | A | G | 32,594 | -0.23 | 2.69E-08 | 16,185 | 0.04 | 4.07E-01 | No |
| MPV | rs11212635 | 11:108310702 | A | T | 40,058 | 0.04 | 9.55E-09 | 17,333 | -0.01 | 3.68E-01 | No |
| TProt | rs8022180 | 14:103263020 | A | G | 38,352 | 0.04 | 7.24E-10 | 19,665 | 0.03 | 2.63E-03 | Yes |
| Trigs | rs6847598 | 4:76750356 | T | C | 23,963 | -0.05 | 1.58E-08 | 12,526 | -0.03 | 1.48E-02 | Yes |
| TSH | rs12590163 | 14:105223525 | T | C | 27,441 | -0.05 | 4.68E-08 | 17,042 | -0.04 | 6.76E-04 | Yes |
| TSH | rs310766 | 3:12233482 | A | G | 27,441 | -0.06 | 1.66E-08 | 17,079 | -0.05 | 1.42E-05 | Yes |
| TSH | rs9275141 | 6:32651117 | T | G | 27,441 | 0.05 | 3.47E-09 | 17,054 | 0.04 | 8.64E-04 | Yes |