Table 1.
Characteristics of included animal studies
| Author; Year; Country | Sample size (control; treated) | Gender; Strain; Species | Injury model | Severity | Injury level | Onset of hypothermia post-injury (min) | Hypothermia duration (min) | Type of hypothermia | Cooling temperature (°C) | Follow up duration (day) |
|---|---|---|---|---|---|---|---|---|---|---|
| Barbosa; 2014; Brazil | 15; 15 | Male and female; Wistar; Rat | Contusion | Moderate | T9-T10 | 0 | 20 | Local | 25 | 42 |
| Batchelor; 2010; Australia | 36; 36 | Female ; Fischer; Rat | Contusion | Moderate | T8 | 30 | 450 | General | 33 | 56 |
| Casas; 2005; USA | 14; 42 | Female ; SD; Rat | Contusion | Moderate | T10 | 30 | 180 | Local | 24±2.3 | 42 |
| Dimar; 2000; USA | 26; 26 | Male; SD; Rat | Contusion | Moderate | T10 | 0 | 120 | Local | 19 | 35 |
| Grulova; 2013; Slovakia | 12; 4 | Male; Wistar; Rat | Compression | Moderate | T8–T9 | 0 | 198 | General | 32.0 | 28 |
| Ha; 2008; Korea | 8; 8 | Male; SD; Rat | Contusion | Severe | T9 | 0 | 2880 | Local | 30 | 7 |
| Hosier; 2015; USA | 10; 8 | Female ; Long-Evans; Rat | Contusion | Severe | C7 | 240 | 240 | General | 33.0±0.3 | 42 |
| Kao; 2011; Taiwan | 8; 8 | Male; SD; Rat | Contusion | Moderate | T8-T9 | 0 | 120 | General | 31 to 35 | 4 |
| Karamouzian; 2015; Iran | 20; 60 | Male; Wistar; Rat | Contusion | Moderate | T8–9 | 30 | 180 | General | 33.5±0.5 | 42 |
| Lo; 2009; USA | 9; 9 | Female; Fischer; Rat | Contusion | Moderate | C5 | 5 | 240 | General | 33.0±0.3 | 56 |
| Maybhate; 2012; USA | 8; 7 | Female; Lewis; Rat | Contusion | Moderate | T8 | 120 | 120 | General | 32 | 28 |
| Morizane; 2012; Japan | 10; 9 | Female ; Wistar; Rat | Contusion | Severe | T11 | 0 | 2880 | Local | 33 | 56 |
| Morochovic; 2008; Slovakia | 10; 10 | Male; SD; Rat | Compression | Severe | T8-T9 | 25 | 60 | Local | 28.5±0.3 | 28 |
| Ok; 2012; Korea | 7; 14 | Male; SD; Rat | Contusion | Severe | T9 | 0 | 2880 | Local and general | 20 | 42 |
| Seo; 2015; Korea | 5; 5 | Male; SD; Rat | Contusion | Moderate | T9 | 15 | 240 | Systemic | 30-32 | 42 |
| Teh; 2017; Singapore | 6; 11 | NR; SD; Rat | Contusion | Moderate | T8 | 120 | 300 | Local | 32±0.5 | 42 |
| Topuz; 2010; Turky | 8; 8 | Male; Wistar; Rat | Compression | Moderate | T10-T12 | 30 | 120 | Local | 27-29 | 42 |
| Westergren; 2000; Sweden | 9; 7 | Male; SD; Rat | Compression | Moderate | T7-T8 | 60 | 120 | General | 30 | 14 |
| Xu; 2016; China | 12; 12 | Male; SD; Rat | Compression | Moderate | T10 | 0 | 160 | Local | 18 | 21 |
| Yu; 2000; USA | 8; 12 | Female ; SD; Rat | Contusion | Moderate | T10 | 30 | 240 | General | 33.1 | 44 |
GMLC: GottingenMinnesotaLiběchov crossbred; SD: Sprague–Dawley