Fig. 7.

CSF p217 + tau correlates modestly with cognition. A) CSF p217 + tau (PT3×HT43) was measured in a small cohort of mild-moderate dementia subjects (n = 21, 90% amyloid positive) and compared with the MMSE scores from the same timepoint. B) CSF p217 + tau (PT3×HT43) was measured in a larger cohort of mild-moderate dementia subjects (n = 235, 87% amyloid positive) and compared with change in MMSE score from time of sample collection to 18 months later. Higher p217 + tau levels were seen in subjects with worse baseline cognition and greater worsening in cognition. C, D) CSF p181tau and t-tau concentrations revealed inferior correlations with change in MMSE.