Table 1.
Demographic and clinical characteristics of the three groups, MCI (established by standard clinical evaluation), univariate cognitive status based on 1, 2 or 3 abnormal scores, or by MNC status
| Standard clinical evaluation | 1 abnormal score z < 1.45 | 2 abnormal scores z< –1.15 | 3 abnormal scores z< –0.70 | MNC status | ||||||
| Normal cognition | MCI | Normal cognition | Abnormal cognition | Normal cognition | Abnormal cognition | Normal cognition | Abnormal cognition | Normal MNC-status | Abnormal MNC-status | |
| N = 215 | N = 204 | N = 152 | N = 267 | N = 185 | N = 234 | N = 145 | N = 274 | N = 224 | N = 195 | |
| (51.3%) | (48.7%) | (36.3%) | (62.7%) | (44.2%) | (55.8%) | (34.6%) | (65.4) | (53.5%) | (46.5%) | |
| Age (SD) | 62.4 (8.8) | 67.1 (7.1) | 63.9 (7.7) | 65.1 (8.7) | 63.9 (8.0) | 65.3 (8.6) | 64.0 (7.8) | 65.0 (8.6) | 64.4 (7.9) | 65.0 (8.8) |
| Sex M/F | 130/85 | 140/64 | 96/56 | 174/93 | 123/62 | 147/87 | 89/56 | 181/93 | 149/75 | 121/74 |
| MMSE | 28.5 (1.3) | 27.1 (1.7) | 28.3 (1.2) | 27.4 (1.8) | 28.4 (1.3) | 27.3 (1.8) | 28.6 (1.3) | 27.4 (1.7) | 28.3 (1.3) | 27.2 (1.8) |
| RAVLT-total | 40.4 (8.9) | 31.0 (7.3) | 41.9 (8.5) | 32.3 (8.1) | 40.8 (8.8) | 31.9 (8.0) | 41.9 (9.0) | 32.6 (8.0) | 39.3 (9.3) | 31.8 (7.9) |
| RAVLT-delayed | 8.1 (2.9) | 3.8 (2.7) | 8.6 (2.6) | 4.5 (3.1) | 8.0 (3.1) | 4.4 (3.0) | 8.3 (3.2) | 4.8 (3.1) | 7.7 (3.0) | 4.1 (3.1) |
| Animal fluency | 22.2 (5.4) | 18.6 (4.7) | 23.4 (5.0) | 18.7 (4.8) | 23.3 (5.1) | 18.1 (4.4) | 23.9 (9.7) | 18.6 (4.7) | 22.2 (5.3) | 18.4 (4.6) |
| COWAT | 35.8 (11.0) | 32.9 (11.6) | 39.5 (9.8) | 31.9 (11.5) | 38.8 (10.4) | 30.8 (10.9) | 39.4 (9.7) | 31.7 (11.3) | 36.6 (10.5) | 31.7 (11.8) |
| TMTa | 39.1 (13.9) | 46.0 (17.5) | 35.6 (10.7) | 46.4 (17.4) | 35.9 (10.5) | 47.6 (17.8) | 34.9 (9.8) | 46.4 (17.3) | 37.5 (11.2) | 48.2 (18.8) |
| TMTb | 89.6 (35.2) | 129.6 (64.6) | 83.9 (26.2) | 123.4 (62.1) | 85.2 (26.5) | 127.8 (64.3) | 83.6 (30.3) | 122.5 (60.6) | 89.6 (31.4) | 131.7 (67.3) |
| Stroop-words | 47.2 (11.9) | 48.5 (10.5) | 43.6 (5.6) | 50.2 (12.9) | 43.5 (5.5) | 51.3 (13.3) | 42.3 (4.6) | 50.8 (12.6) | 44.9 (6.1) | 51.2 (14.1) |
| Stroop-colors | 64.4 (15.1) | 68.0 (15.5) | 59.2 (8.5) | 70.2 (17.0) | 59.3 (8.3) | 71.7 (17.4) | 57.6 (8.2) | 70.7 (16.4) | 60.9 (9.2) | 72.3 (18.5) |
| Stroop-col.word | 108.5 (29.2) | 128.5 (41.2) | 100.0 (18.4) | 128.7 (41.4) | 100.9 (21.7) | 132.0 (41.4) | 98.3 (21.8) | 128.8 (39.6) | 103.0 (21.5) | 135.8 (43.7) |
MMSE, Mini-Mental State Examination; RAVLT, Rey Auditory Verbal Learning Test; COWAT, Controlled Oral Word Association Test; TMT, Trail Making Test; Stroop, Stroop Color-Word Test.