Fig. 1.

TSPO overexpression in the brain and in peripheral organs in TgF344-AD rats. The ex vivo measures of [¹²⁵I]CLINDE concentrations (% injected dose -ID-/g of tissue) were performed in the hippocampus (A), in various brain areas (B), in the eyes (C), and in various peripheral organs (D) in wild-type (WT) and TgF344-AD rats at the age of 12 and 24 months. [¹²⁵I]CLINDE concentrations were analyzed by two-way ANOVA. Post hoc tests indicate genotype differences at the same age (★  ) and age effects in TgF344-AD (∞). The number of symbols indicates the significance level (1: p < 0.05; 2: p < 0.01; 3: p < 0.001). Mean±SEM of 8 animals per genotype and per age are presented. BRes., brain residue; Cer., cerebellum; Col., colon; Cx, frontal cortex; Duo., proximal duodenum; Kid., kidney; Liv., liver; Spl., spleen; Stria., striatum.