Fig. 2.
Cell origin identification of TSPO overexpression in the hippocampus of TgF344-AD rats. The [125I]CLINDE concentrations were determined in 24-month-old wild-type animals (WT) and in 12- and 24-month-old (12 m and 24 m) TgF344-AD rats. A) Radioactivity was determined in GLT1+ (astrocytes), CD11b+ (microglia), and CD31+ (endothelial cells) cell population (% injected dose/g of tissue). B) Radioactivity per cell (% injected dose/cell) in each cell population. C) number of cells sorted. [125I]CLINDE concentrations and cell number were analyzed by two-way ANOVA. Post hoc tests indicate genotype differences (★ ) and age effects in TgF344-AD (∞). The number of symbols indicates the significance level (1: p < 0.05; 2: p < 0.01; 3: p < 0.001). Mean±SEM of 8 animals per genotype and per age are presented.