Fig. 4.
Determination of the cell origin of TSPO overexpression in temporal cortex of Alzheimer’s disease. The [125I]CLINDE concentrations were determined in the temporal cortex of control and AD subjects. A) Radioactivity was determined in GLT1+ (astrocytes), CD45+ (microglia), and CD31+ (endothelial cells) cell population (% injected dose/g of tissue). B) Radioactivity per cell (% injected dose/cell) in each cell population. C) number of cells sorted. [125I]CLINDE concentrations and cell number were analyzed by two-way ANOVA. Post hoc tests indicate genotype differences (★ p < 0.05). Mean±SEM of 8-9 subjects per group are presented.