Table 2.

Change in CGI-S and CGI-I scores over 8 weeks of treatment with pimavanserin as monotherapy vs adjunctive therapy

		Monotherapy		Adjunctive Therapy
CGI-S	n	Change from baseline	n	Change from baseline
		LS mean (SE)		LS mean (SE)
Week 2	20	–1.1 (0.18)	23	–0.9 (0.23)
Week 4	20	–1.5 (0.19)	19	–1.5 (0.21)
Week 6	18	–1.7 (0.20)	21	–1.5 (0.18)
Week 8	19	–1.9 (0.21)	20	–1.6 (0.22)
CGI-I	n	LS mean (SE)	n	LS mean (SE)
Week 2	19	2.4 (0.21)	23	2.6 (0.26)
Week 4	20	2.1 (0.20)	19	2.3 (0.23)
Week 6	18	1.9 (0.19)	21	2.2 (0.22)
Week 8	19	1.8 (0.20)	20	2.2 (0.25)

Clinicians rated the severity of the patient’s depression and improvement of symptoms from baseline on a scale of 1–7, with lower scores indicating improvement. CGI-I, Clinical Global Impression–Improvement; CGI-S, Clinical Global Impression–Severity; LS, least squares; SE, standard error.