Table 3.
Brain failure and survival outcomes per SIRI group.
| Characteristic | All patients (N = 181) | SIRI < 1.73 (N = 96) | SIRI > 1.73 (N = 85) | P value |
|---|---|---|---|---|
| Brain failure, n (%) | ||||
| Present | 15 (8.2) | 11 (11.5) | 4 (4.7) | 0.014 |
| Absent | 166 (91.8) | 85 (88.5) | 81 (95.3) | |
| Brain failure pattern, n (%) | ||||
| None | 15 (8.2) | 11 (11.5) | 4 (4.7) | 0.53 |
| Infield | 140 (77.4) | 73 (76.0) | 67 (78.7) | |
| Marginal | 14 (7.7) | 4 (4.2) | 10 (11.8) | |
| Distant | 5 (2.8) | 3 (3.1) | 2 (2.4) | |
| Infield and distant | 4 (2.2) | 3(3.1) | 1 (1.2) | |
| Marginal and distant | 3 (1.7) | 2 (2.1) | 1 (1.2) | |
| PFS | ||||
| Median, mo (95% CI) | 10.3 (7.2-13.4) | 16.2 (14.5-17.9) | 6.6 (3.1-8.9) | <0.001 |
| 2 years (%) | 11.9 | 29.5 | 5.0 | |
| 5 years (%) | 6.6 | 11.9 | 0 | |
| OS | ||||
| Median, mo (95% CI) | 15.8 (12.5-19.1) | 22.9 (19.8-26.0) | 12.2 (9.7-14.6) | <0.001 |
| 2 years, % | 27.2 | 44.6 | 5.5 | |
| 5 years, % | 8.2 | 15.3 | 0 |
Abbreviations: SIRI: systemic immune response index; CI: confidence interval; PFS: progression-free survival; OS: overall survival.