Table 4.
Results of uni- and multivariate analysis.
| Variable | PFS | OS | ||||
|---|---|---|---|---|---|---|
| Univariate P value | Multivariate P value | Hazard ratio | Univariate P value | Multivariate P value | Hazard ratio | |
| Age (≤50 vs. >50 years) | 0.17 | — | — | 0.14 | — | — |
| Gender (male vs. female) | 0.84 | — | — | 0.92 | — | — |
| KPS (90-100 vs. 70-80) | 0.002 | 0.008 | 1.48 | 0.001 | 0.005 | 1.57 |
| RTOG RPA group (III-IV vs. V) | <0.001 | <0.001 | 1.98 | <0.001 | <0.001 | 2.14 |
| Symptom duration (<3 vs. ≥3 months) | 0.42 | — | — | 054 | — | — |
| Extent of resection (GTR vs. STR/biopsy) | 0.006 | 0.014 | 1.72 | 0.009 | 0.019 | 1.68 |
| IDH status (positive vs. negative) | <0.001 | <0.001 | 2.33 | <0.001 | <0.001 | 2.94 |
| RT technique (3D-CRT vs. SIB-IMRT) | 0.91 | — | — | 0.94 | — | — |
| RT dose (60 vs. 70 Gy) | 0.43 | — | — | 0.55 | — | — |
| SIRI group (<1.78 vs. ≥1.78) | <0.001 | <0.001 | 2.07 | <0.001 | <0.001 | 2.77 |
Abbreviations: PFS: progression-free survival; OS: overall survival; KPS: Karnofsky performance score; RTOG-RPA: radiation therapy oncology group recursive partitioning analysis; GTR: gross total resection; STR: subtotal resection; IDH: isocitrate dehydrogenase; 3D-CRT: 3-dimensional conformal radiotherapy; SIB-IMRT: simultaneous integrated boost intensity-modulated radiotherapy; RT: radiotherapy; SII: systemic immune-inflammation index; SIRI: systemic immune response index.