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OMT decreases oxidative stress in SH-SY5Y cells treated with high glucose: (a) ROS levels; (b) NOX2 and (c) NOX4 mRNA expression levels; (d) NOX2 and (e) NOX4 protein expression levels; (f) NOX activity. Data are presented as the mean ± standarddeviation. ∗P < 0.05 vs. control; #P < 0.05, ##P < 0.01 vs. glucose. Glucose: 30 mM/l glucose; glucose+oxymatrine: 30 mM/l glucose+8 μM OMT; glucose+vehicle: glucose+DMSO. OMT: oxymatrine; NOX: NADPH oxidase.
