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. 2020 Nov 16;2020:3912173. doi: 10.1155/2020/3912173

Figure 8.

Figure 8

Knockdown of NOX2 and NOX4 reduced oxidative stress and apoptosis in SH-SY5Y cells treated with high glucose. (a, b) NOX2 and NOX4 siRNA transfection effectively reduced NOX2 and NOX4 expression levels. (c, d) NOX2 and NOX4 siRNA transfection effectively downregulated NOX2 and NOX4 expression levels in SH-SY5Y cells treated with high glucose and OMT. (e, f) NOX2 and NOX4 siRNA transfection effectively decreased ROS levels in SH-SY5Y cells treated with high glucose and OMT. Data are presented as the mean ± standarddeviation. ∗P < 0.05, ∗∗P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. glucose. OMT: oxymatrine; NOX: NADPH oxidase; ROS: reactive oxygen species; siRNA: small interfering RNA.