Fig. 4. Effect of PF on the protein expression of iNOS, COX-2, pNF-κB, and IκB-α in Aβ_25–35-treated C6 glial cells. ‘Control’ represents non-treated cells, ‘Aβ’ represents Aβ_25–35-treated cells, ‘PF1’, ‘PF5’, or ‘PF10’ represent the 3 concentrations of paeoniflorin treatment (1, 5, and 10 μg/mL, respectively) in Aβ_25–35-treated cells. Values are mean ± SD.

iNOS, inducible NO synthase; Aβ, amyloid beta; PF, paeoniflorin; COX-2, cyclooxygenase-2; pNF-κB, phospho nuclear factor-kappa B; IκB-α, inhibitor kappa B-alpha.

^a-dMeans with different letters are significantly different (P < 0.05) as determined by Duncan's multiple range test.