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. 2020 Nov 3;23(12):101763. doi: 10.1016/j.isci.2020.101763

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Akr1a1b Knockout in Zebrafish Caused Alterations of the Embryonic Pronephros

(A) Compared with akr1a1b^+/+ embryos (n = 33, mean ± SD) at 48 hpf, Δ+17 akr1a1b^-/- mutants (n = 21, mean ± SD) displayed an enlarged glomerulus (encircled) and shortened tubular neck (asterisk). (B) Representative pronephros images of 48hpf old akr1a1b^+/+ and Δ+17 akr1a1b^-/- embryos.

(C) A significant increased loss of fluorescence in Δ+17akr1a1b^-/- mutants (n = 18, mean ± SD) was observed when compared with akr1a1b^+/+ larvae (n = 21, mean ± SD), which indicated an altered glomerular filtration rate in akr1a1b^-/- mutants.

∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001, p value was calculated by t test. Scale bar: 0.1 mm.