Figure 4.

CL-Induced Beiging Leads to an Interferon/Stat1 Response

(A) Heatmap of differentially expressed genes in Mac1 cluster of iWAT from mice after 3 days of CL or cold treatment.

(B) Venn diagram of up (left) and down (right) regulated genes within Mac1 cluster after 3 days of CL or cold treatment.

(C) GO-driven pathway analysis of DE downregulated gene by cold in Mac1.

(D) Violin plots for the expression of interferon response genes (expression in each cell is shown along with the probability density of gene expression).

(E) Representative images of immunohistochemistry of P-Stat1 (Tyr701) in iWAT section from mice treated for 3 days with vehicle, CL, or cold.