Fig. 3. Correspondence across phenotypes of cortical neuron types.

a, Quantitative morphological clustering and electrophysiological feature variation between major inhibitory neuron classes using transgenic mouse lines (modified from Figs. 1 and 2 from ref. ³¹). b, Convergent physiological, anatomical and transcriptomic evidence for a distinctive rosehip layer 1 inhibitory neuron type in human cortex that differs from neighboring neurogliaform cells. c, Morphological and physiological differences between layer 1 neurogliaform and single bouquet neurons shown by patch-seq analysis. Scale bars as in b. d, RNA-seq analysis of retrogradely labeled neurons in mouse primary visual cortex show distinctive projections of excitatory subclasses, but overlapping projections for finer transcriptomic cell types. Images in a adapted with permission from ref. ³¹, Oxford Univ. Press; in b–d, adapted with permission from refs. ^75,76 and ⁴⁰, respectively, Springer Nature.