. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: NMR Biomed. 2020 Jun 17;33(9):e4346. doi: 10.1002/nbm.4346

Table 1.

DT metrics estimates (mean ± standard deviation, unadjusted p-values (bold indicates values that remain significant after Bonferroni correction for 8 dMRI comparisons), Cohen’s d and the percentage differences for ROI. Mean (MD), axial (D_∥) and radial (D_⊥) diffusivities, fractional anisotropy (FA); fimbria (Fi), fornix (Fx), corpus callosum (CC), internal (IC) and external (EC) capsule, dorsal (DH) and ventral (VH) hippocampus.

		Mean (MD)	Axial (D_∥)	Radial (D_⊥)	FA
		Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
		μm²/ms	μm²/ms	μm²/ms
Fi	NC	0.979 ± 0.049	1.758 ± 0.062	0.589 ± 0.051	0.595 ± 0.027
	3xTg-AD	1.006 ± 0.036	1.755 ± 0.049	0.632 ± 0.038	0.568 ± 0.020
	p-values	0.0031	0.7898	<.0001	<.0001
	Cohen’s d	0.655	−0.054	0.970	−1.206
	% Difference	2.800	−0.171	7.252	−4.621
Fx	NC	0.954 ± 0.061	1.462 ± 0.058	0.700 ± 0.079	0.449 ± 0.044
	3xTg-AD	0.957 ± 0.043	1.458 ± 0.047	0.706 ± 0.062	0.441 ± 0.042
	p-values	0.8025	0.679	0.6559	0.3607
	Cohen’s d	0.054	−0.084	0.091	−0.187
	% Difference	0.294	−0.301	0.900	−1.761
CC	NC	0.866 ± 0.021	1.321 ± 0.037	0.639 ± 0.027	0.476 ± 0.020
	3xTg-AD	0.875 ± 0.019	1.285 ± 0.037	0.671 ± 0.021	0.441 ± 0.018
	p-values	0.0295	<.0001	<.0001	<.0001
	Cohen’s d	0.449	−0.987	1.335	−1.865
	% Difference	1.016	−2.755	4.913	−7.389
IC	NC	0.808 ± 0.018	1.285 ± 0.036	0.570 ± 0.019	0.479 ± 0.021
	3xTg-AD	0.818 ± 0.017	1.303 ± 0.025	0.575 ± 0.021	0.479 ± 0.019
	p-values	0.0092	0.0091	0.203	0.9003
	Cohen’s d	0.541	0.581	0.261	−0.026
	% Difference	1.163	1.362	0.930	−0.104
EC	NC	0.840 ± 0.029	1.121 ± 0.036	0.699 ± 0.030	0.329 ± 0.016
	3xTg-AD	0.848 ± 0.024	1.132 ± 0.030	0.706 ± 0.026	0.322 ± 0.016
	p-values	0.127	0.0928	0.2426	0.0418
	Cohen’s d	0.313	0.345	0.239	−0.419
	% Difference	0.965	0.999	0.944	−2.037
DH	NC	0.789 ± 0.022	0.888 ± 0.033	0.740 ± 0.018	0.121 ± 0.012
	3xTg-AD	0.803 ± 0.022	0.906 ± 0.037	0.752 ± 0.016	0.122 ± 0.016
	p-values	0.0019	0.0125	0.0006	0.7775
	Cohen’s d	0.648	0.517	0.720	0.058
	% Difference	1.774	2.050	1.622	0.741
VH	NC	0.796 ± 0.021	0.890 ± 0.027	0.749 ± 0.019	0.122 ± 0.007
	3xTg-AD	0.809 ± 0.020	0.916 ± 0.028	0.756 ± 0.017	0.131 ± 0.008
	p-values	0.0022	<.0001	0.0723	<.0001
	Cohen’s d	0.639	0.948	0.369	1.129
	% Difference	1.633	2.932	0.854	7.201