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. 2020 Nov 10;14:599710. doi: 10.3389/fnint.2020.599710

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Copyright © 2020 Matzeu and Martin-Fardon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Experimental procedure. Somatic withdrawal sign (WDS) scores were recorded upon the completion of training. (B) During weeks 1–3 of CIE vapor exposure, BALs were measured 15 min before the EtOH vapors were turned off (on Fridays), and the rats were scored for WDS 8 h (i.e., acute abstinence) after the EtOH vapor was turned off (on Thursdays). (C) During weeks 4–6 of CIE vapor exposure, the rats underwent self-administration sessions (Monday, Wednesday, and Friday) when acute abstinence occurred (8 h after the vapor was turned off). (D) During weeks 7–8 of CIE vapor exposure, the rats were exposed to daily extinction sessions during acute abstinence (8 h after the EtOH vapor was turned off). BAL, blood alcohol level; WDS, somatic withdrawal signs; W, week.