TABLE 2.
Metabolic pathway enrichment analysis based on p-value no more than 0.05.
| # | ID annotation | Annotation | Match status | RichFactor | p-value | -lg(p-value) | FDR correction |
| 1 | ame00230 | Purine metabolism | 13/95 | 0.136842105 | 2.1276E-05 | 4.672109906 | 0.000776574* |
| 2 | ame02010 | ABC transporters | 13/126 | 0.103174603 | 0.000410312 | 3.386885643 | 0.009984262* |
| 3 | ame00310 | Lysine degradation | 8/55 | 0.145454545 | 0.000590325 | 3.22890873 | 0.010773434* |
| 4 | ame00564 | Glycerophospholipid metabolism | 7/52 | 0.134615385 | 0.002088801 | 2.680102851 | 0.0304965* |
| 5 | ame00250 | Alanine, aspartate and glutamate metabolism | 5/28 | 0.178571429 | 0.002623066 | 2.581190834 | 0.031913966* |
| 6 | ame01230 | Biosynthesis of amino acids | 11/128 | 0.0859375 | 0.005034777 | 2.298019803 | 0.052505526 |
| 7 | ame01210 | 2-Oxocarboxylic acid metabolism | 11/134 | 0.082089552 | 0.007107752 | 2.148267725 | 0.057864678 |
| 8 | ame04150 | mTOR signaling pathway | 2/4 | 0.5 | 0.007134001 | 2.146666812 | 0.057864678 |
| 9 | ame00970 | Aminoacyl-tRNA biosynthesis | 6/52 | 0.115384615 | 0.009365324 | 2.028477182 | 0.059827478 |
| 10 | ame04080 | Neuroactive ligand-receptor interaction | 6/52 | 0.115384615 | 0.009365324 | 2.028477182 | 0.059827478 |
| 11 | ame00600 | Sphingolipid metabolism | 4/25 | 0.16 | 0.010654208 | 1.97247881 | 0.059827478 |
| 12 | ame00565 | Ether lipid metabolism | 4/25 | 0.16 | 0.010654208 | 1.97247881 | 0.059827478 |
| 13 | ame04068 | FoxO signaling pathway | 2/5 | 0.4 | 0.01161524 | 1.93497183 | 0.060565178 |
| 14 | ame00630 | Glyoxylate and dicarboxylate metabolism | 6/62 | 0.096774194 | 0.021249264 | 1.672656108 | 0.103413085 |
| 15 | ame00740 | Riboflavin metabolism | 3/20 | 0.15 | 0.031869127 | 1.496629829 | 0.136849782 |
| 16 | ame00020 | Citrate cycle (TCA cycle) | 3/20 | 0.15 | 0.031869127 | 1.496629829 | 0.136849782 |
| 17 | ame00360 | Phenylalanine metabolism | 6/72 | 0.083333333 | 0.040654726 | 1.390888959 | 0.164877501 |
Match Status = Hit/Total. The Total is the total number of compounds in the pathway; the Hits is the actually matched number. The p-value is the originally calculated from the enrichment analysis; the −lg(p-value) is the p-value adjusted by logarithm operation based on 10; the FDR is the p value adjusted using False Discovery Rate results from the pathway analysis. *FDR < 0.05.