Table 3.
Variables (both original and alternative grading) and 5-year disease-specific survival in univariate calculations for the whole cohort, and for low-stage disease and high-stage disease separately. The percentage of patients surviving according to different grading is specified under DSS%
| Whole cohort (n = 150) | Low-stage (n = 78) | High-stage (n = 63) | |||||
|---|---|---|---|---|---|---|---|
| Variables | All | All | All | ||||
| DSS % | p (n) | DSS% | p (n) | DSS% | p (n) | ||
| 1.0 | Differentiation, whole tumor | 92.3/64.0/16.7 | < 0.001 (127)* | 94.7/84.6/40.0 | 0.002 (63)* | 75.0/47.7/0 | 0.055 (55) |
| 1.1 | 70.4/16.7 | < 0.001* | 87.7/40.0 | 0.001* | 51.1/0 | 0.025 * | |
| 2.0 | Differentiation, worst pattern | 100/72.0/56.7 | 0.074 (124) | 100/88.9/76.9 | 0.248 (63) | 100/50.0/40.0 | 0.646 (54) |
| 2.1 | 75.4/56.7 | 0.053 | 90.9/76.7 | 0.121 | 52.6/40.0 | 0.676 | |
| 3.0 | Keratinization whole tumor | 85.0/68.0/53.6/47.6 | 0.038 (124)* | 82.4/91.3/83.3/66.7 | 0.402 (61) | 83.3/46.2/30.8/22.2 | 0.137 (54) |
| 3.1 | 73.3/51.0 | 0.010 * | 87.5/76.2 | 0.238 | 53.1/27.3 | 0.078 | |
| 4.0 | Keratinization, tumor front | /100/70.3/59.7 | 0.047 (120)* | ÷/100/89.5/75.8 | 0.133 (62) | ÷/100/47.1/44.1 | 0.665 (52) |
| 4.1 | 100/63.3 | 0.025* | 100/80.8 | 0.146 | 100/45.1 | 0.374 | |
| 5.0 | Nuclear polymorphism | 84.0/64.4/60.0/52.0 | 0.147(125) | 100/85.7/84.6/50.0 | 0.004 (62)* | 33.3/42.1/40.0/50.0 | 0.767 (54) |
| 5.1 | 71.4/56.4 | 0.097 | 92.3/69.6 | 0.018* | 40.0/44.8 | 0.673 | |
| 6.0 | Nuclear polymorphism, tumor front | 66.7/75.0/68.8/57.5 | 0.507 (120) | 100/94.7/64.2/64.7 | 0.054 (63) | 20.0/46.7/40.0/54.5 | 0.363 (52) |
| 6.1 | 72.9/62.5 | 0.302 | 96.2/75.0 | 0.029* | 40.0/50.0 | 0.343 | |
| 7.0 | Perineural infiltration | 70.0/52.9/28.6 | 0.003 (114)* | 84.0/71.4/50.0 | 0.250 (59) | 52.8/33.3/20.0 | 0.046 (50)* |
| 7.1 | 70.0/45.8 | 0.020* | 84.0/66.7 | 0.208 | 52.8/28.6 | 0.098 | |
| 8.0 | Lymphocytic infiltration | 87.5/67.2/50.0 | 0.008 (123)* | 100/87.5/56.3 | 0.003 (63)* | 62.5/40.0/47.6 | 0.711 (54) |
| 8.1 | 87.5/60.0 | 0.021* | 100/77.1 | 0.050* | 62.5/43.5 | 0.409 | |
| 8.2 | 72.9/50.0 | 0.007* | 91.5/56.3 | 0.001* | 45.5/47.6 | 0.821 | |
| 9.0 | WPOI | 100/70.6/82.8/58.9/56.3 | 0.190 (120) | 100/80.0/100/77.8/66.7 | 0.224 (62) | ÷/50.0/50.0/42.3/50.0 | 0.997 (52) |
| 9.1 | 73.7/65.3 | 0.461 | 83.3/84.0 | 0.999 | 50,0/45.7 | 0.908 | |
| 9.2 | 79.2/58.3 | 0.022* | 93.1/75.8 | 0.061 | 50.0/44.4 | 0.902 | |
*Significant at 0.05 level