Table V.
Binary PC-SAFT interaction parameters between excipients and APIs
| FFB | IBU | IND | CBZ | GRI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
|
| TG808080 | −0.107 [9] | 0.00030 | −0.1370 [9] | 0.00040 | 0.024 [9] | 0 | 0.175 * | 0 | 0.031 * | 0 |
| DG100100 | −0.032 * | 0 | 0.028 * | 0 | −0.013 * | 0 | 0.040 * | 0 | 0.020 * | 0 |
| MG80 | −0.032 * | 0 | 0.028 * | 0 | −0.013 * | 0 | 0.040 * | 0 | 0.020 * | 0 |
| MC80 | −0.113 * | 0.00028 | 0.027 * | 0 | 0.008 * | 0 | 0.028 * | 0 | 0.028 * | 0 |
| Lauroglycol FCC | −0.038 * | 0 | 0.007 * | 0 | 0.011 * | 0 | 0.097 * | 0 | 0.039 * | 0 |
| Capryol 90 | −0.034 * | 0 | 0.003 * | 0 | 0.003 * | 0 | 0.064 * | 0 | 0.025 * | 0 |
| TPGS1000 | −0.030 * | 0 | 0.006 * | 0 | −0.014 * | 0 | 0.023 * | 0 | −0.007 * | 0 |
| carbitol | −0.013 * | 0 | 0 | 0 | −0.009 * | 0 | 0.029 * | 0 | 0.018 * | 0 |
| PEG400 | 0.028 * | 0 | 0 | 0 | 0.004 * | 0 | −0.012 * | 0 | 0.011 * | 0 |
| ethanol | 0.033 [9] | 0 | 0.1458 * | −0.00030 | 0.0309 [33] | −0.00008 | 0.079 [34] | −0.00015 | 0.032 * | 0 |
| GLI | NAP | CIN | PZQ | FEL | ||||||
|
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
kij, int [−] |
kij, slope [T−1] |
|
| TG808080 | 0.024 * | 0 | 0.041 * | 0 | 0.026 * | 0 | 0.017 * | 0 | 0.007 * | 0 |
| DG100100 | 0.010 * | 0 | 0.008 * | 0 | −0.006 * | 0 | −0.039 * | 0 | 0.000 * | 0 |
| MG80 | 0.010 * | 0 | 0.008 * | 0 | −0.006 * | 0 | −0.039 * | 0 | 0.000 * | 0 |
| MC80 | 0.033 * | 0 | 0.018 * | 0 | −0.034 * | 0 | 0.000 * | 0 | 0.024 * | 0 |
| Lauroglycol FCC | 0.044 * | 0 | 0.034 [17] | 0 | 0.026 * | 0 | 0.005 * | 0 | 0.019 * | 0 |
| Capryol 90 | 0.023 * | 0 | 0.013 [17] | 0 | 0.019 * | 0 | 0.007 * | 0 | 0.005 * | 0 |
| TPGS1000 | −0.011 * | 0 | −0.003 [17] | 0 | 0.005 * | 0 | 0.023 * | 0 | −0.016 * | 0 |
| carbitol | 0.008 * | 0 | −0.011 * | 0 | 0.006 * | 0 | 0.014 * | 0 | 0.003 * | 0 |
| PEG400 | 0.000 * | 0 | −0.017 * | 0 | 0.010 * | 0 | 0.058 * | 0 | 0.011 * | 0 |
| ethanol | −0.024 [35] | 0.00013 | −0.001 [33] | 0 | 0.004 * | 0 | 0.020 * | 0 | 0.002 * | 0 |
*The supporting experimental data can be obtained on request