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. 2020 Jul 31;382(3):463–476. doi: 10.1007/s00441-020-03249-y

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© The Author(s) 2020

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Fig. 2 — Single-cell RNA sequencing analysis of midbrain-specific organoids. (a) Uniform manifold approximation and projection (UMAP) plot shows that the total 1295 cells identified 8 cell populations. Each dot corresponds to a single cell. Cell populations are coloured and annotated based on their expressing genes. CP, cycling progenitors; MC, mesenchymal cells; RG, radial glia cells; Ex/Inhi N, excitatory/inhibitory neurons; mNeu, mature neurons. UMAP plots shows difference in gene expressions between day 35 and day 70. (b) Dot plot shows the expression of each cell type–specific genes. (c–d) Violin plots show the distribution of expression of each marker gene. The mNeu clusters expressed MAP2 (c) and NEFL (c’), the Ex/Inhi N clusters expressed GPC2 (d) and KCNJ6 (d’)