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. 2020 Nov 10;8:566090. doi: 10.3389/fcell.2020.566090

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Copyright © 2020 Yang and Malarkannan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional regulations downstream of mTOR complexes. The essential regulation of crucial transcription factors downstream of mTORC1 and mTORC2 are shown employing the observations made with distinct knockout mice. mTORC1 regulates the expression of Eomes and thereby the early developmental stages of NK cells. mTORC2 regulates the reciprocal repressive activity between FoxO1 and T-bet. FoxO1 represses the expression of T-bet, thereby maintaining the immature gene signature. T-bet suppresses the expression of FoxO1 to make the NK cells progress to the terminally mature NK cell stage.