Figure 1.

Schematic representation of the liver and the single end of its lobule. The portal triad comprising the hepatic artery, bile duct, and portal vein sits at each end of the hepatic lobule. Blood collected from the portal vein and hepatic artery flows toward the central vein through the hepatic sinusoids lined by liver sinusoidal endothelial cells (LSEC) and hepatocytes. The hepatocytes and LSECs are separated by the perisinusoidal space, also known as space of Dissé where hepatic stellate cells (HSC) are located. The hepatocytes produce bile which empties into the bile duct lined by cholangiocytes. The canal of Hering is positioned in the junctional region between cholangiocytes and hepatocytes, where liver progenitor cells (LPC) are proposed to originate.