Fig. 6. Diagnosis and therapeutic evaluation of EMDs before and after Sino 19 cell infusion.

B-ALL presented as a large breast mass in a patient with EMDs. a Computed tomography shows a large mass in the right breast (red arrow). b Flow cytometry on a breast mass sample acquired by puncture biopsy: shows CD19 and CD10 positive B lymphoblasts. c Cell morphology (Wright–Giemsa staining) shows lymphoblasts. At least three smears from this aspirated mass tissue were produced and stained, then three pathologists independently performed morphological view and evaluation, the final diagnosis was established when they had the consistent findings. Scale bar: 50 μM. d Computed tomography shows disappeared large mass at Day 50 following Sino 19 cell infusion (red arrow).