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. 2020 Nov 24;6:87. doi: 10.1038/s41421-020-00211-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Map of H3K4me3 marks, C/EBPβ binding sites, P1 and P2 sites of CHIP-PCR on the promoter region of Nr4A1. b CHIP-PCR in BMDM of wt and LncLy6C KO (LNC KO), control BMDM (NC), and butyrate-treated BMDMs (butyrate). % input was compared. Iso isotypic antibody. c QRT-PCR of Nr4A1 in BMDM of wt and LncLy6C KO (LNC KO) (left) or control BMDM (NC) and butyrate-treated BMDMs (Buty) (right). d Immunoblotting of Nr4A1 in BMDM of wt and LncLy6C KO (LNC KO) or control BMDM (NC) and butyrate-treated BMDMs (butyrate). e Immunoblotting of Nr4A1 in the BMDM of wt and LncLy6C KO (LNC KO) after exposed to different concentration of butyrate. f Map of butyrate-mediated lncLy6C to regulate the expression of Nr4A1. Butyrate-induced LncLy6C may promote the expression of Nr4A1 through binding with C/EBP and lysine methyltransferases of H3K4me3. One-way ANOVA and Bonferroni’s multiple comparison test in b. Two-sided Student’s t test in c.