Table 3.
Characteristics of the individuals with autoantibodies giving score 3 by IHC or positive for known or to novel NSAbs at wave 3.
| No. | Sex | Age (year) | IHC score/patterna | Titer by IHC | CBA | Staining on live neurons | Diagnosisb | Anxiety/depression onset age (year) | Anti-depressants usage during the last 2 years | Fever/coldc | Chronic comorbidities |
|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | Male | 66 | 3/A | Not tested | Negative | Negative | Remitted depression | –/35 | No | No | Rheumatism: fibromyalgia; hay fever, house dust allergy |
| P2 | Female | 46 | 3/B | 12800 | Negative | Positive | Current anxiety | 8/– | No | Cold | Hay fever |
| P3 | Male | 55 | 3/B | 6400 | Negative | Positive | Current anxiety, remitted depression (single episode) | 53/14 | No | Cold | Hypertension |
| P4 | Female | 58 | 3/B | 800 | Negative | Positive | Current anxiety and depression | 56/56 | No | Cold | Chronic bronchitis; diarrhea; eczema; psoriasis |
| P5 | Female | 57 | 3/C | 3200 | Negative | Positive | Current anxiety | 55/– | No | Cold | Hypertension; breast cancer; eczema; arthritis; renal pelvic inflammation with encapsulated kidney stone; chronic heart conditions (unspecified) |
| P6 | Female | 31 | 3/C | 3200 | Negative | Positive | Current anxiety, remitted depression (single episode) | 29/20 | No | No | No |
| P7 | Female | 58 | 3/C | Not tested | Negative | Negative | Remitted anxiety and depression | 16/36 | No | No | Diabetes; arthritis; benign connective tissue tumor; allergy |
| P8 | Male | 66 | 3/D | Not tested | Negative | Negative | Current depression | –/45 | Yes | No | No |
| P9 | Male | 56 | 2/E | 1600 | Negative | Positive | Current anxiety, remitted depression (single episode) | 48/28 | No | No | Eczema |
| P10 | Female | 36 | 2/F | 1600 | Negative | Positive | Current anxiety and depression | 35/34 | No | No | Chronic heart conditions (unspecified); ligament injury |
| P11 | Male | 53 | 1/H | Not tested | CASPR2 positive (live and fixed CBA) | Negative | Remitted depression | –/51 | Yes | No | Hypertension; asthma; arthritis; hay fever; |
| P12 | Male | 66 | 2/GAD pattern | Not tested | GAD65/67 positive | Negative | Current depression | –/61 | No | No | Diabetes, hypertension; arteriosclerosis, heart disease, chronic bronchitis; rheumatism; arthritis; constipation; |
| C1 | Male | 20 | 2/K | 400 | Negative | Positive | None (Control group) | –/– | No | No | Injury (overloading of the knee) |
aIHC novel pattern: 11 different novel IHC patterns were found in this study (see Fig. 1, A–K).
bCurrent: diagnosed with depression and/or anxiety within 6-month when blood samples were collected. Remitted: diagnoses with depression and/or anxiety earlier in life but no diagnoses of depression or anxiety within 6-month when blood samples were collected.
cHad a fever or a cold in the past week before the blood sample was drawn based on questionnaires.