Table 3.
Accuracy for outcome prediction of in-hospital mortality over different test cut-points.
| Sensitivity (95% CI) | Specificity (95% CI) | NPV (95% CI) | PPV (95% CI) | AUC (95% CI) | |
|---|---|---|---|---|---|
| tSIRS ≥ 2 (n = 2859) | 82.2 (78.2–85.8) | 17.7 (16.2–19.3) | 85.6 (82.2–88.5) | 14.4 (13.0–15.8) | 0.50 (0.48–0.52) |
| maxSIRS ≥ 2 (n = 2859) | 98.1 (96.2–99.2) | 2.2 (1.8–2.8) | 81.4 (66.6–91.6) | 14.3 (13.0–15.7) | 0.50 (0.49–0.50) |
| Initial lactate ≥ 3 mmol/L (n = 2306) | 67.8 (62.4–72.8) | 57.4 (55.2–59.6) | 91.5 (89.9–93.0) | 20.8 (18.4–23.3) | 0.63 (0.60–0.65) |
| Repeat Lactate ≥ 3 mmol/L (n = 1320) | 54.8 (48.4–61.1) | 76.1 (73.5–78.6) | 87.9 (85.7–90.0) | 34.7 (30.0–39.6) | 0.65 (0.62–0.69) |
| Lactate clearance ≥ 10% (n = 1320) | 66.1 (59.9–72.0) | 17.7 (15.5–20.1) | 69.3 (63.5–74.7) | 15.7 (13.5–18.0) | 0.42 (0.39–0.45) |
| tqSOFA ≥ 2 (n = 2845) | 32.9 (28.4–37.7) | 84.7 (83.2–86.1) | 88.3 (86.9–89.6) | 26.4 (22.6–30.4) | 0.59 (0.56–0.61) |
| qSOFA ≥ 2 (n = 2840) | 69.0 (64.2–73.4) | 55.5 (53.5–57.5) | 91.5 (89.9–92.8) | 20.6 (18.4–22.8) | 0.62 (0.60–0.65) |
Overall mortality rate in severe sepsis dataset: 14.3% (95% CI: 13.0% to 15.6%).