Table 1.

Affinity of TDP-43 variants and Aβ interaction. The rate constants k_on, k_off, and K_D defined as k_off/k_on were determined by Octet RED96 system to probe the interaction between TDP-43 and Aβ40.

	kon (1/Ms)	koff (1/s)	KD(M)
TDP-43_FL	3.4 × 104	<1.0 × 10−7	<1.0 ×  10-12
TDP-43_265	5.7 × 103	5.6 × 10-4	9.9 × 10-8
TDP-43_N-term	N.D.	N.D.	N.D.
TDP-43_RRM1 + 2	9.0 × 103	<1.0 × 10-7	<1.0 × 10-12

N.D.: unable to be determined due to absence of significant binding signal.