Table 3. Hazard ratios (HRs) and their 95% confidence intervals (95% CIs) for esophageal cancer risk according to combined categories of smoking, alcohol drinking and green tea consumption.
| Smoking* | Alcohol† | Green tea‡ | Cohort 1 | Cohort 2 | |||
| No. of cases/ person-years |
HR (95% CI)§ | No. of cases/ person-years |
HR (95% CI)§ | Pooled | |||
| HR (95% CI)§ | |||||||
| − | − | − | 1 / 7508.1 | 1.00 (referent) | 1 / 15933.7 | 1.00 (referent) | 1.00 (referent) |
| ＋ | − | − | 0 / 5208.6 | - | 2 / 18334.4 | 2.30 (0.21-25.5) | - |
| − | ＋ | − | 2 / 4351.8 | 4.40 (0.40-48.8) | 1 / 12685.7 | 1.31 (0.08-20.9) | 2.61 (0.42-16.07) |
| − | − | ＋ | 4 / 11729.7 | 2.47 (0.28-22.2) | 1 / 14726.1 | 0.86 (0.05-13.7) | 1.65 (0.29- 9.19) |
| ＋ | ＋ | − | 5 / 7357.4 | 7.25 (0.83-63.0) | 13 / 22276.9 | 11.4 (1.49-87.3) | 9.23 (2.10-40.60) |
| ＋ | − | ＋ | 7 / 10889.1 | 5.65 (0.69-46.2) | 5 / 16676.3 | 4.39 (0.51-37.6) | 4.99 (1.11-22.43) |
| − | ＋ | ＋ | 1 / 7074.2 | 1.21 (0.08-19.4) | 4 / 9365.4 | 5.20 (0.58-46.6) | 2.97 (0.53-16.58) |
| ＋ | ＋ | ＋ | 18 / 12956.6 | 12.2 (1.61-92.5) | 13 / 19612.9 | 10.0 (1.31-76.7) | 11.1 (2.63-46.51) |
* : Currently smoking
† : Daily alcohol drinking
‡ : Daily consumption of ≥3 cups/day
§ : Adjusted for age in years, coffee consumption (never or occasionally, 1-2 cups/day, ≥3 cups/day), and black tea consumption (never or occasionally, ≥1 cup/day).