Table 2.
Recurrent mutants in the SPOP gene target three codons.
| Variant | Count | Gene | Mutant | IAR | Frequency |
|---|---|---|---|---|---|
| chr17:49619064A>C | 5 | SPOP | p.F133V | RFVQGKDWG V KKFIRRDFL | 4 |
| chr17:49619063A>C | 3 | SPOP | p.F133C | RFVQGKDWG C KKFIRRDFL | 2 |
| chr17:49619064A>T | 2 | SPOP | p.F133I | RFVQGKDWG I KKFIRRDFL | 1 |
| chr17:49619062G>T | 2 | SPOP | p.F133L | RFVQGKDWG L KKFIRRDFL | 2 |
| chr17:49619281A>C | 2 | SPOP | p.F102C | CPKSEVRAK C KFSILNAKG | 2 |
| chr17:49619282A>C | 3 | SPOP | p.F102V | CPKSEVRAK V KFSILNAKG | 3 |
| chr17:49619070A>C | 2 | SPOP | p.W131G | AYRFVQGKD G GFKKFIRRD | 2 |
The F133V/C/I/L mutant may be of interest as a universal neoepitope due to the similar chemical properties of Leucine, Isoleucine and Valine.