TABLE 1.
Demographic characteristics and cognitive test scores of study participants (age ≥60, non‐missing education and race/ethnicity, non‐missing Trail A, Trail B, category fluency [animals], and category fluency [vegetables])
| Version 2 (N = 4318)* | Version 3 (N = 4318) | |||||
|---|---|---|---|---|---|---|
| CDR = 0N = 2274 | CDR = 0.5N = 1722 | CDR = 1N = 322 | CDR = 0N = 2274 | CDR = 0.5N = 1722 | CDR = 1N = 322 | |
| Age, y (mean, SD) | 71.6 (7.4) | 73.2 (7.5) | 74.7 (7.8) | 71.2 (6.5) | 72.6 (7.0) | 74.8 (7.6) |
| Education, y (mean, SD) | 16.0 (2.9) | 15.7 (3.3) | 15.2 (3.1) | 16.3 (2.7) | 16.0 (2.9) | 15.5 (3.1) |
| Female (%) | 64.0 | 45.2 | 45.7 | 65.3 | 50.6 | 46.3 |
| Race (%) | ||||||
| Caucasian | 76.4 | 82.2 | 88.8 | 76.4 | 82.2 | 88.8 |
| African American | 16.2 | 12.5 | 6.2 | 16.2 | 12.5 | 6.2 |
| American Indian or Alaska Native | 0.6 | 0.8 | 1.2 | 1.2 | 0.7 | 0 |
| Native Hawaiian or Pacific Islander | 0 | 0.1 | 0.3 | 0.1 | 0 | 0.3 |
| Asian | 2.7 | 1.5 | 1.6 | 3.5 | 2.3 | 3.4 |
| Multiracial | 4.1 | 2.9 | 1.9 | 2.6 | 2.3 | 1.2 |
| Cognitive Test Scores | ||||||
|
Common tests across two versions (V2 and V3 are matched using the following 4 tests and therefore by design the distributions are similar between V2 and V3 cohorts) |
||||||
| Animals | 20.7 (5.5) | 16.4 (5.4) | 12.2 (5.1) | 20.7 (5.6) | 16.5 (5.5) | 12.2 (5.1) |
| Vegetables | 14.4 (4.0) | 10.7 (4.2) | 7.2 (3.6) | 14.4 (4.1) | 10.8 (4.3) | 7.3 (3.7) |
| Trail A | 33.7 (13.6) | 43.2 (22.4) | 59.6 (32.8) | 33.7 (13.9) | 43.1 (22.7) | 59.7 (32.0) |
| Trail B | 90.0 (47.0) | 138.1 (80.2) | 210.9 (89.3) | 90.5 (48.1) | 138.2 (80.1) | 209.1 (88.8) |
| V2 specific tests | ||||||
| MMSE | 28.9 (1.3) | 26.7 (2.8) | 23.1 (3.7) | |||
| Logical memory immediate recall | 13.1 (3.8) | 8.9 (4.4) | 5.3 (3.9) | |||
| Logical memory delayed recall | 11.9 (4.0) | 6.7 (4.9) | 3.2 (4.1) | |||
| Digit span forward | 8.5 (2.0) | 7.8 (2.0) | 7.4 (2.1) | |||
| Digit span backward | 6.7 (2.2) | 5.8 (2.1) | 4.9 (2.0) | |||
| Boston naming test | 27.1 (3.1) | 24.7 (5.0) | 21.4 (6.9) | |||
| Digit symbol | 47.1 (11.3) | 38.2 (12.2) | 28.8 (12.7) | |||
| V3 specific tests | ||||||
| MoCA | 25.9 (2.8) | 22.1 (4.1) | 17.1 (4.5) | |||
| Craft Story immediate recall (verbatim scoring) | 21.4 (6.6) | 15.1 (7.3) | 9.5 (5.9) | |||
| Craft Story delayed recall (verbatim scoring) | 18.5 (6.6) | 11.1 (7.8) | 4.2 (5.5) | |||
| Number span forward test (correct trials) | 8.1 (2.3) | 7.5 (2.3) | 7.0 (2.3) | |||
| Number span backward test (correct trials) | 6.9 (2.2) | 5.9 (2.1) | 5.0 (2.1) | |||
| Multilingual naming test (MINT) (total score) | 29.8 (2.5) | 27.8 (4.7) | 24.7 (6.2) | |||
| Copy of Benson Figure (total score) | 15.5 (1.4) | 15.0 (2.0) | 14.1 (3.1) | |||
| Delayed drawing of Benson figure (total score) | 11.1 (3.0) | 7.3 (4.4) | 3.5 (3.9) | |||
| MoCA in V3 converted to MMSE using Cross Walk results (Monsell, et al) 23 | 28.9 (1.4) | 26.7 (2.8) | 23.0 (3.8) | 29.1 (1.3) | 26.9 (3.0) | 23.0 (4.0) |