TABLE 3.
ROC‐AUC for MoCA index scores and domain specific composite scores in Version 3: comparisons between (1) MoCA Index vs Composite and (2) Caucasian participants vs African American participants
| All subjects (n = 4318) | African American subjects (n = 604) | Caucasian subjects (n = 3439) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Test | CDR 0 vs 0.5 | CDR 0 vs 1 | CDR 0.5 vs 1 | CDR 0 vs 0.5 | CDR 0 vs 1 | CDR 0.5 vs 1 | CDR 0 vs 0.5 | CDR 0 vs 1 | CDR 0.5 vs 1 |
| MoCA memory index | 0.779 | 0.945 | 0.760 | 0.692 | 0.923 | 0.791 | 0.795* | 0.945 | 0.749 |
| (0.764, 0.794) | (0.931, 0.958) | (0.733, 0.788) | (0.647, 0.737) | (0.849, 0.997) | (0.69, 0.893) | (0.779, 0.811) | (0.931, 0.958) | (0.718, 0.78) | |
| MoCA executive index | 0.704## | 0.888## | 0.743# | 0.669 | 0.948** | 0.845* | 0.711** | 0.878 | 0.731 |
| (0.687, 0.72) | (0.868, 0.908) | (0.713, 0.773) | (0.622, 0.716) | (0.908, 0.987) | (0.769, 0.921) | (0.692, 0.729) | (0.855, 0.902) | (0.698, 0.765) | |
| MoCA language index | 0.658 | 0.803 | 0.672 | 0.633 | 0.856** | 0.719* | 0.667** | 0.794 | 0.661 |
| (0.64, 0.675) | (0.777, 0.829) | (0.639, 0.704) | (0.586, 0.681) | (0.769, 0.943) | (0.599, 0.84) | (0.647, 0.686) | (0.765, 0.823) | (0.625, 0.697) | |
| MoCA attention index | 0.688## | 0.848## | 0.709# | 0.661 | 0.905** | 0.775* | 0.700** | 0.838 | 0.698 |
| (0.671, 0.705) | (0.824, 0.872) | (0.677, 0.741) | (0.614, 0.708) | (0.852, 0.959) | (0.677, 0.872) | (0.681, 0.718) | (0.811, 0.866) | (0.663, 0.733) | |
| MoCA visuospatial index | 0.679## | 0.837## | 0.690 | 0.631 | 0.901** | 0.793 | 0.688** | 0.825 | 0.678 |
| (0.662, 0.696) | (0.814, 0.861) | (0.658, 0.722) | (0.582, 0.679) | (0.842, 0.96) | (0.708, 0.878) | (0.669, 0.707) | (0.798, 0.852) | (0.643, 0.714) | |
| MoCA orientation index | 0.704 | 0.919 | 0.788 | 0.667 | 0.943 | 0.833 | 0.711 | 0.916 | 0.780 |
| (0.688, 0.721) | (0.90, 0.938) | (0.76, 0.817) | (0.619, 0.715) | (0.889, 0.996) | (0.744, 0.922) | (0.693, 0.73) | (0.895, 0.937) | (0.749, 0.811) | |
| Memory composite score | 0.805# | 0.959 | 0.797 | 0.715 | 0.952 | 0.827 | 0.822** | 0.960 | 0.790 |
| (0.791, 0.819) | (0.945, 0.973) | (0.770, 0.824) | (0.670, 0.759) | (0.900, 1.000) | (0.730, 0.924) | (0.807, 0.837) | (0.945, 0.974) | (0.760, 0.820) | |
| Executive function composite score | 0.617 | 0.771 | 0.682 | 0.631 | 0.831 | 0.700 | 0.605 | 0.748 | 0.673 |
| (0.599, 0.634) | (0.743, 0.799) | (0.650, 0.714) | (0.582, 0.680) | (0.733, 0.928) | (0.587, 0.812) | (0.585, 0.626) | (0.716, 0.780) | (0.639, 0.708) | |
| Language composite score | 0.740## | 0.913## | 0.743## | 0.683 | 0.926 | 0.792 | 0.755** | 0.910 | 0.727 |
| (0.724, 0.756) | (0.895, 0.930) | (0.714, 0.773) | (0.637, 0.730) | (0.879, 0.974) | (0.691, 0.894) | (0.737, 0.772) | (0.891, 0.929) | (0.695, 0.760) | |
| Attention composite score | 0.614 | 0.738 | 0.649 | 0.618 | 0.853** | 0.746** | 0.605 | 0.709 | 0.634 |
| (0.596, 0.632) | (0.708, 0.767) | (0.615, 0.683) | (0.569, 0.667) | (0.769, 0.936) | (0.655, 0.837) | (0.585, 0.625) | (0.674, 0.743) | (0.596, 0.672) | |
| Visuospatial composite score | 0.633 | 0.755 | 0.647 | 0.618 | 0.864** | 0.745** | 0.627 | 0.733 | 0.640 |
| (0.615, 0.651) | (0.726, 0.784) | (0.613, 0.682) | (0.569, 0.667) | (0.792, 0.936) | (0.649, 0.841) | (0.607, 0.647) | (0.700, 0.767) | (0.602, 0.678) | |
| UDS‐3 Global composite score | 0.747 | 0.908 | 0.722 | 0.653 | 0.875 | 0.756 | 0.767** | 0.910 | 0.712 |
| (0.731, 0.763) | (0.888, 0.929) | (0.691, 0.753) | (0.605, 0.700) | (0.778, 0.972) | (0.640, 0.872) | (0.749, 0.784) | (0.889, 0.932) | (0.678, 0.745) | |
| Global composite score | 0.748 | 0.905 | 0.724 | 0.660 | 0.913 | 0.796 | 0.765** | 0.907 | 0.717 |
| (0.732, 0.764) | (0.887, 0.923) | (0.692, 0.755) | (0.613, 0.707) | (0.863, 0.963) | (0.705, 0.887) | (0.748, 0.782) | (0.887, 0.926) | (0.682, 0.751) | |
*: P < 0.05, **: P < 0.01. Statistically significant difference in comparing between African American subjects and Caucasians
#: P < 0.05, ## : P < 0.01. Statistically significant difference in comparing between MoCA Index and UDS Composites
The test which showed better ability is indicted by * or ** (comparison between racial groups), or by # or ## (comparison between MoCA Index and UDS composite scores).
Adjusted for age, gender, and years of education. For regression involving all subjects, additional adjustment for race.
MoCA Memory Index Score is composed of the number of words recalled in delayed free, category‐cued, and multiple‐choice conditions.
MoCA Executive Index Score is composed of trail‐making, clock, digit span, letter A tapping, serial 7 subtraction, letter fluency, and abstraction.
MoCA Visuospatial Index Score is composed of cube copy, clock, and naming.
MoCA Language Index Score is composed of naming, sentence repetition, and letter fluency.
MoCA Attention Index Score is composed of digit span, letter A tapping, serial 7 subtraction, sentence repetition, and words recalled in both immediate recall trials.
MoCA Orientation Index Score is composed of all orientation items.
*: P < 0.05, **: P < 0.01. Statistically significant difference in comparing between African American subjects and Caucasians
#: P < 0.05, ## : P < 0.01. Statistically significant difference in comparing between MoCA Index and UDS Composites
The test which showed better performance is indicted by * or ** (comparison between racial groups) or by # or ## (comparison between MoCA Index and UDS composite scores).
Adjusted for age, gender, and years of education. For regression involving all subjects, additional adjustment for race.
UDS Memory Composite Score is composed of immediate craft story recall (paraphrase scoring), delayed craft story recall (paraphrase scoring), total score for delayed drawing of Benson figure, and MoCA memory index score.
UDS Language Composite Score is composed of category fluency (animals), category fluency (vegetables), MINT total score, number of correct F‐words and L‐words, and MoCA language index.
UDS Attention Score is composed of trail making test part A, forward number span test (correct trials), and MoCA attentional index.
UDS Executive Function Score is composed of trail making test part B, backward number span test (correct trials), and MoCA executive functions index.
UDS Visuospatial Score is composed of total score for copy of Benson figure and MoCA Visuospatial Index.
UDS Global Composite‐5 Score is the average of 5 domain specific composite scores.
UDS Global Composite‐3 Score is composed of MoCA total score, delayed craft story recall, and trail making test part B.