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. 2020 Nov 23;10:20382. doi: 10.1038/s41598-020-77290-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Photobiomodulation protects retinal function, assessed by ERG analysis. (a) Shows representative ERG waveforms measured in dark-adapted sham-treated (black) and 830 nm PBM-treated (red) P23H rats by ISCEV protocol³⁴ at the lowest (10mcd.s/m²) and the highest flash intensities (3000 and 10,000 mcd.s/m²). 830 nm PBM treatment improved the b-wave response at low stimulus intensities and the a and b wave responses at higher stimulus intensities. (b) Illustrates standard flicker response in the ISCEV protocol (3 cd.s/m² @ 30 Hz) representing cone function in sham-treated and PBM-treated rats. Representative flicker responses are shown in P23H (black) and PBM-treated P23H (red) rats. There was no statistical significance observed in the flicker response between the sham-treated and 830 nm PBM-treated rats. (c) and (d) show the mean a-wave and mean b-wave ERG amplitudes (respectively) measured by scotopic intensity series protocol comparing P23H transgenic retina (filled square) and 830 nm treated P23H retina (filled triangle). 830 nm PBM treatment produced a significant increase in both a-wave (F_(1,14) = 16.32, p < .001; n = 8) and b-wave amplitudes (F_(1,22) = 23.57, p < .001; n = 12) at all flash intensities compared to the P23H group. Error bars: SE.