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. 2020 Nov 23;10:20382. doi: 10.1038/s41598-020-77290-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The therapeutic effect of PBM diminishes following the termination of treatment. (a) shows the total retinal thickness of 830 nm PBM treated P23H rats and sham-treated P23H rats monitored from p18 to p80 in a longitudinal SD-OCT study. The retinoprotective effects of 830 nm PBM administered from p10–p25 diminished as the animals matured and statistically significant differences (p < .01) between the sham-treated and 830 nm PBM-treated groups were found at p25 and p32, but not beyond this time. Error bars: SE. (b) shows representative linear scans at p18, p25, p32, p39, and p80.