Table 2.
Individual animals examined for histological analysis.
| ID | Phenotype | Age (months) | IBA1 | LAMP1 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WM | ML | GL | DCN | WM | ML | GL | DCN | |||
| 670 | MPS IIIB | 3 | 0.4 | 3.8 | 3.6 | 4.0 | 2.2338 | 1.1984 | 0.0810 | 0.1509 |
| 676 | MPS IIIB | 3 | 1.8 | 10.2 | 1.0 | 0.7 | 2.3489 | 4.1601 | 0.1048 | 0.1681 |
| 340 | MPS IIIB | 9 | 20.2 | 42.3 | 60.1 | 20.7 | 0.2562 | 1.5429 | 0.1434 | 1.9971 |
| 292 | MPS IIIB | 9 | 6.2 | 8.1 | 9.2 | 5.4 | 0.0022 | 0.0094 | 0.0000 | 0.0002 |
| 302 | MPS IIIB | 15 | 5.1 | 6.8 | 8.7 | 10.7 | 1.2043 | 0.0007 | 10.7174 | 24.9239 |
| 326 | MPS IIIB | 16.6 | 9.0 | 10.3 | 9.4 | 25.8 | 0.3975 | 0.0003 | 0.4723 | 12.3951 |
| 328 | MPS IIIB | 16.6 | 6.0 | 6.2 | 5.6 | 13.9 | 0.5270 | 0.0001 | 0.3418 | 2.0102 |
| 227 | MPS IIIB | 25 | 11.1 | 14.0 | 10.2 | 9.7 | 6.4790 | 1.5660 | 7.9240 | 34.7327 |
| 200 | MPS IIIB | 28 | 12.0 | 11.5 | 11.3 | 15.0 | 0.1783 | 0.0004 | 0.1189 | 2.5216 |
| 197 | MPS IIIB | 28 | 14.8 | 15.3 | 19.9 | 24.9 | 0.0003 | 0.0005 | 0.0094 | 0.2200 |
| 674 | Unaffected | 3 | 0.2 | 2.9 | 0.2 | 1.7 | 4.8459 | 0.2378 | 4.4699 | 0.2684 |
| 675 | Unaffected | 3 | 0.5 | 2.4 | 0.4 | 0.9 | 0.8453 | 5.2396 | 1.7916 | 4.1729 |
| 208 | Unaffected | 9 | 2.2 | 8.2 | 8.9 | 2.1 | 0.0006 | 0.0011 | 0.0002 | 0.0002 |
| 210 | Unaffected | 9 | 4.8 | 14.0 | 12.6 | 4.2 | 0.0000 | 0.0078 | 0.0023 | 0.0000 |
| 93 | Unaffected | 15 | 4.4 | 9.8 | 9.2 | 2.6 | 0.0000 | 0.0009 | 0.0001 | 0.0006 |
| 99 | Unaffected | 15 | 5.1 | 7.7 | 7.9 | 1.9 | 0.0003 | 0.0000 | 0.0012 | 0.0021 |
| 132 | Unaffected | 22 | 7.2 | 8.9 | 9.2 | 4.5 | 0.0004 | 0.0000 | 0.0092 | 0.1325 |
| 323 | Unaffected | 22 | 5.3 | 11.3 | 10.2 | 2.0 | 0.0019 | 0.0000 | 0.0043 | 0.0400 |
Individual animal IDs, ages and thresholding image analysis data collected from the cerebellum for the microglial marker IBA1 and for lysosomal membrane associated protein 1 (LAMP1). Regions measured include cerebellar white matter (WM), molecular layer (ML), granule cell layer (GL) and deep cerebellar nucleus (DCN).