Table 2.

Urinary concentration estimates of BPA and TCS. 50th and 95th EDI values obtained by reverse dosimetry from urinary concentrations, were used as daily doses in forward dosimetry in order to evaluate the generic models. The ICF results were obtained for BPA only, as TCS did not reach steady state in the model. The ICF scenarios for normal and obese child were used, however using the same input weight, i.e. a body weight of 35.2 kg for the boy and 31.6 kg for the girl, respectively. For the Httk model, virtual populations as described in Section 2.4.2.2 were used for the simulation of BPA and TCS. Using the 50th and 95th percentile EDI as input to the model, the resulting minimum (min), maximum (max), and median urinary concentrations for the virtual populations are shown.

Boys
		EDI	HTTK simulated results (ng/mL)			ICF simulated results, normal child (ng/mL)	ICF simulated results, obese child (ng/mL)	Measured urine (ng/mL)
	Percentile	mg/kg/day	min	max	median
BPA	50th	8.0E-05	0.01	0.88	0.04	13.00	14.82	3.33
	95th	3.1E-04	0.02	3.12	0.15	51.05	58.21	7.75
TCS	50th	2.8E-05	0.0002	0.03	0.001	–	–	1.45
	95th	1.4E-02	0.09	16.76	0.48	–	–	186.18
Girls
		EDI	HTTK simulated results (ng/mL)			ICF simulated results, normal child (ng/mL)	ICF simulated results, obese child (ng/mL)	Measured urine (ng/mL)
	Percentile	mg/kg/day	min	max	median
BPA	50th	4.97E-05	0.00	0.65	0.02	8.11	9.24	2.20
	95th	3.16E-04	0.02	4.16	0.15	51.54	58.77	11.20
TCS	50th	1.88E-05	0.0001	0.02	0.001	–	–	0.80
	95th	1.23E-02	0.06	12.63	0.41	–	–	37.01