Table 3.
The list of the possible ICU mortality predicting variables as a result of univariate binary logistic regression; independent ICU mortality predictors derived from the multivariate binary logistic regression*
| ICU survivors |
ICU non-survivors |
Univariate binary logistic regression |
Multivariate binary logistic regression |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | p | OR | 95% CI lower | 95% CI upper | p | OR | 95% CI lower | 95% CI upper | ||||
| Age (med; IQR) |
69.5 |
59.25-82.75 |
77.5 |
69.25-81.75 |
0.070 |
1.03 |
0.998 |
1.06 |
||||
| Sex (male) (No; %) |
29 |
40.3% |
24 |
54.5% |
0.136 |
1.78 |
0.83 |
3.80 |
||||
| CHD (No; %) |
22 |
30.6% |
25 |
56.8% |
0.006 |
2.99 |
1.37 |
6.52 |
||||
| COPD (No; %) |
10 |
13.9% |
12 |
27.3% |
0.079 |
2.33 |
0.91 |
5.96 |
||||
| CVD (No; %) |
15 |
20.8% |
23 |
52.3% |
0.001 |
4.16 |
1.83 |
9.46 |
||||
| CKD (No; %) |
22 |
30.6% |
23 |
52.3% |
0.021 |
2.49 |
1.15 |
5.41 |
||||
| DM (No; %) |
23 |
31.9% |
20 |
45.5% |
0.146 |
1.78 |
0.82 |
3.85 |
||||
| Reduced mobility (No; %) |
24 |
33.3% |
34 |
77.3% |
<0.001 |
6.80 |
2.88 |
16.05 |
0.002 |
11.15 |
2.45 |
50.91 |
| Unrecognized sepsis in ED (fever) (No; %) |
8 |
11.1% |
11 |
25.0% |
0.055 |
2.67 |
0.98 |
7.27 |
0.040 |
6.59 |
1.09 |
39.75 |
| GCS (med; IQR)† |
14 |
13.0-15.0 |
11 |
10.0-13.0 |
<0.001 |
0.46 |
0.35 |
0.61 |
nt |
nt |
nt |
nt |
| SOFA score (med; IQR)† |
4 |
3.0-6.0 |
8 |
6.0-10.0 |
<0.001 |
2.23 |
1.69 |
2.94 |
<0.001 |
2.37 |
1.59 |
3.52 |
| MAP (mmHg) (mean; SD)† |
87.1 |
±15.9 |
73.9 |
±19.2 |
<0.001 |
0.96 |
0.93 |
0.98 |
nt |
nt |
nt |
nt |
| Heart rate (bpm) (med; IQR)† |
98 |
80-119.5 |
117 |
95.0-126.75 |
0.036 |
1.02 |
1.001 |
1.03 |
||||
| Tax (°C) (med; IQR)† |
37.0 |
36.5-38.5 |
36.5 |
36.5-38.0 |
0.215 |
0.77 |
0.51 |
1.16 |
||||
| Septic shock (No; %) |
15 |
20.8% |
26 |
59.1% |
<0.001 |
5.49 |
2.40 |
12.56 |
nt |
nt |
nt |
nt |
| MODS (No; %) |
34 |
47.2% |
41 |
93.2% |
<0.001 |
15.28 |
4.33 |
53.86 |
||||
| pH (med; IQR)† |
7.38 |
7.32-7.46 |
7.37 |
7.26-7.43 |
0.034 |
0.08 |
0.01 |
0.83 |
||||
| BE (med; IQR)† |
-3.45 |
(-7.38)-0.28 |
-5.60 |
(-10.1)-(-1.3) |
0.215 |
0.97 |
0.93 |
1.02 |
||||
| RBC ( × 1012/L) (mean; SD)† |
4.12 |
±0.85 |
4.46 |
±0.74 |
0.033 |
1.71 |
1.04 |
2.81 |
||||
| Hemoglobin (g/L) (mean; SD)† |
118.3 |
±23.6 |
126.4 |
±22.9 |
0.076 |
1.02 |
0.998 |
1.03 |
||||
| Platelet count (x109/L) (med; IQR)† |
236.0 |
162.5-348.8 |
173.0 |
103.5-260.2 |
0.019 |
0.996 |
0.993 |
0.999 |
nt |
nt |
nt |
nt |
| PT (%) (med; IQR)† |
72.5 |
56.0-91.75 |
51.5 |
30.75-78.5 |
0.002 |
0.98 |
0.96 |
0.99 |
||||
| Lactate (mmol/L) (med; IQR)† |
1.5 |
0.9-2.3 |
2.1 |
1.4-4.8 |
0.152 |
1.77 |
0.81 |
3.88 |
||||
| CRP (mg/L) (med; IQR)† |
241.6 |
147.6-306.5 |
193.5 |
66.9-302.6 |
0.153 |
0.998 |
0.995 |
1.001 |
||||
| Empirical antimicrobial treatment only (No; %) |
15 |
20.8% |
36 |
81.8% |
<0.001 |
17.10 |
6.59 |
44.40 |
0.001 |
9.99 |
2.57 |
38.87 |
| No of antibiogram guided antibiotics (med; IQR) |
1 |
0.0-2.0 |
0 |
0.0-2.0 |
<0.001 |
0.10 |
0.04 |
0.25 |
||||
| Mechanical ventilation (No; %) | 5 | 6.9% | 13 | 29.5% | 0.002 | 5.62 | 1.84 | 17.15 | nt | nt | nt | nt |
*BE – base excess; bpm – beats per minute; CHD – chronic heart disease; CKD – chronic kidney disease; COPD – chronic obstructive pulmonary disease; CRP – C-reactive protein; CVD – cerebrovascular disease; DM – diabetes mellitus; ED – emergency department; GCS – Glasgow Coma Score; ICU – intensive care unit; MAP – mean arterial pressure; MODS – multiple organ dysfunction syndrome; PT – prothrombin time; RBC – red blood count; SOFA – Sequential Organ Failure Assessment; Tax – body temperature measured axillary. IQR – interquartile range; med – median; nt – not tested in multivariate binary logistic regression, variables are part of SOFA score; OR – odds ratio, CI – confidence interval; SD – standard deviation.
†values measured at admission to ICU.