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Proposed novel model for CO2 and NH3 transport across the basolateral and apical membranes of αIC cell in the CD. NKCC2 (Na-K-2Cl cotransporter). AE1 (chloride bicarbonate exchanger). CA II (carbonic anhydrase II). This mechanism, particularly the aspects related to CO2 movements, is an extension to the models proposed by others (Gruswitz et al. 2010). The dashed arrows represent the possible diffusion of CO2 or NH3 across plasma membranes.
