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. 2020 Oct 15;15(11):2937–2944. doi: 10.1021/acschembio.0c00568

Table 2. MIC Values (μg/mL) for Compounds 1–8 against the Primary Panel of Bacteria and Fungi, along with IC50 Values (μg/mL) against HepG2 Cells and Haemolysis Frequencies (ESBL, extended-spectrum β-lactamase; MRSA, methicillin-resistant S. aureus).

      compound
pathogen strain type 1 2 3 4 5 6 7 8
E. coli LMG15862 β-lactam. 4 8 16 32 >32 16 8 16
A. baumannii LMG1041T WT 4 8 16 16 32 16 8 16
E. cloacae LMG2783T WT 16 32 32 32 >32 32 16 16
K. pneumoniae LMG20218 ESBL 8 16 32 >32 32 32 16 16
P. aeruginosa LMG6395T WT 16 16 32 >32 32 32 8 16
S. aureus LMG15975 MRSA >32 32 >32 >32 >32 32 16 16
B. cereus CCUG7414T   >32 >32 32 32 16 32 16 32
A. fumigatus J7   >32 >32 >32 >32 >32 >32 >32 >32
C. albicans H-29 WT 32 32 32 >32 >32 >32 >32 >32
IC50(μM) HepG2 liver 29 50 29 9 13 9 11 14
IC50(μg/mL) HepG2 liver 33 56 33 10 14 10 13 16
Hemolysis (%)     4.2 0.8 3.0 9.1 5.2 27.5 14.1 52.3