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. 2020 Oct 15;15(11):2937–2944. doi: 10.1021/acschembio.0c00568

Table 3. Selected MIC Values (μg/mL) for Compound 2 after Testing against an Extended Panel Bacterial Isolates (WT, wild type; MDR, multidrug-resistant; Col, Colistin; CARBA, Carbapenem; ESC, Extended-spectrum cephalosporin; CIP, Ciprofloxacin; GEN, Gentamicin; SXT, Trimethoprim-sulfamethoxazole; mcr-1, Mobilized colistin resistance gene; AMK, Amikacin; TET, Tetracycline).

pathogen strain ID type/resistance pattern MIC
A. baumannii ATCC19606 WT 8
A. baumannii BM4454 MDR clinical 8
A. baumannii BM4652 efflux-defective derivative of BM4454 8
A. baumannii EN0287 Col 8
A. baumannii A219 CARBA 2a
A. baumannii A250 CARBA 2a
E. coli ATCC25922 WT 8
E. coli CH3130 ΔtolC mutant isogenic to ATCC25922 8
E. coli D22 lpxC mutant, hypersensitive 4
E. coli CH3491 ESC, CIP, GEN, SXT 8
E. coli CH9623 mcr-1 2
E. coli CH9624 mcr-1 2
E. coli ATCC25922 WT 1a
E. coli EC4129 CARBA 2a
E. coli EC4163 CARBA 1a
K. pneumoniae ATCC13833 WT 4
K. pneumoniae 1161486 WT 8
K. pneumoniae 1161486a ΔtolC mutant isogenic to 1161486 8
K. pneumoniae CH3498 ESC, CARBA, CIP, GEN, AMK, SXT, TET SXT, TET 8
K. pneumoniae CH9625 Col 4
K. pneumoniae CH9626 Col 4
P. aeruginosa PAO1 WT 32
P. aeruginosa PAO750 efflux-defective isogenic to PAO1 32
P. aeruginosa ATCC27853 WT 4a
P. aeruginosa PS826 CARBA 4a
P. aeruginosa PS992 CARBA 4a
a

Determined at the Public Health Agency of Sweden.