Table 3. Selected MIC Values (μg/mL) for Compound 2 after Testing against an Extended Panel Bacterial Isolates (WT, wild type; MDR, multidrug-resistant; Col, Colistin; CARBA, Carbapenem; ESC, Extended-spectrum cephalosporin; CIP, Ciprofloxacin; GEN, Gentamicin; SXT, Trimethoprim-sulfamethoxazole; mcr-1, Mobilized colistin resistance gene; AMK, Amikacin; TET, Tetracycline).
pathogen | strain ID | type/resistance pattern | MIC |
---|---|---|---|
A. baumannii | ATCC19606 | WT | 8 |
A. baumannii | BM4454 | MDR clinical | 8 |
A. baumannii | BM4652 | efflux-defective derivative of BM4454 | 8 |
A. baumannii | EN0287 | Col | 8 |
A. baumannii | A219 | CARBA | 2a |
A. baumannii | A250 | CARBA | 2a |
E. coli | ATCC25922 | WT | 8 |
E. coli | CH3130 | ΔtolC mutant isogenic to ATCC25922 | 8 |
E. coli | D22 | lpxC mutant, hypersensitive | 4 |
E. coli | CH3491 | ESC, CIP, GEN, SXT | 8 |
E. coli | CH9623 | mcr-1 | 2 |
E. coli | CH9624 | mcr-1 | 2 |
E. coli | ATCC25922 | WT | 1a |
E. coli | EC4129 | CARBA | 2a |
E. coli | EC4163 | CARBA | 1a |
K. pneumoniae | ATCC13833 | WT | 4 |
K. pneumoniae | 1161486 | WT | 8 |
K. pneumoniae | 1161486a | ΔtolC mutant isogenic to 1161486 | 8 |
K. pneumoniae | CH3498 | ESC, CARBA, CIP, GEN, AMK, SXT, TET SXT, TET | 8 |
K. pneumoniae | CH9625 | Col | 4 |
K. pneumoniae | CH9626 | Col | 4 |
P. aeruginosa | PAO1 | WT | 32 |
P. aeruginosa | PAO750 | efflux-defective isogenic to PAO1 | 32 |
P. aeruginosa | ATCC27853 | WT | 4a |
P. aeruginosa | PS826 | CARBA | 4a |
P. aeruginosa | PS992 | CARBA | 4a |
Determined at the Public Health Agency of Sweden.