FIGURE 3.

Effects of diosmin and diosmetin on glucose intolerance in mice fed a HFHS diet. (a) The fasting glucose level after more than 10 hr of fasting in mice fed a HFHS diet was higher than that in the ND group. Diosmin treatment, but not diosmetin treatment, significantly decreased the fasting glucose level. The GTT (b) and AUC (c) results over 3 hr showed that diosmin and diosmetin supplementation attenuated the increase in glucose level induced by the HFHS diet. Values are presented as mean ± SE based on ANOVA (n = 10 mice per group). The different lowercase letters indicate significant differences among all groups, p < .05