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. 2020 Nov 23;12:182. doi: 10.1186/s13148-020-00976-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Interactions between DNA methylation and mitochondria. Arrows refer to different phenomena. (1) nDNAm: Nuclear DNA methylation impact on mitochondrial metabolism. (2) nDNA expression: Influence of nuclear gene expression on enzymes which may cause mtDNA methylation. (3) Metabolites: Effect of mitochondrial metabolites on nDNA methylation. (4) mtDNA SNPs: Burden of mtDNA mutations and haplogroups on nDNA methylation. Metabolites are presented in purple; DNA methylation sites are shown in yellow; DNA mutations are displayed in pink; orange refers to enzymes