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. Author manuscript; available in PMC: 2021 May 28.
Published in final edited form as: J Med Chem. 2020 May 6;63(10):5501–5525. doi: 10.1021/acs.jmedchem.0c00442

Scheme 3.

Scheme 3.

Synthesis of 16a-16c.

Reagents and conditions: (a) hydrazine monohydrate, methanol, reflux, yield 90–95%; (b) propionaldehyde, MgSO4, ethanol, yield 60–70%; (c) NaBH3CN, HCl, methanol, H2O, methyl orange, yield 60–70%; (d) TFA, DCM, yield 60–70%.