Skip to main content
. Author manuscript; available in PMC: 2021 May 28.
Published in final edited form as: J Med Chem. 2020 May 6;63(10):5501–5525. doi: 10.1021/acs.jmedchem.0c00442

Table 4.

IC50 of 13a against HDAC1–9.

HDAC Classes HDAC isotypes IC50a of 13a (nM) IC50 of Panobinostat (nM)65 IC50a of Entinostat (nM)
Class I HDAC1 4.69±1.28 2.5 53.89±5.29
HDAC2 46.0±5.39 13.2 108.2±8.28
HDAC3 0.28±0.12 2.1 77.18±6.30
HDAC8 1755±110.2 277 >10,000
Class IIa HDAC4 >10,000 203 >10,000
HDAC5 >10,000 7.8 >10,000
HDAC7 >10,000 531 >10,000
HDAC9 >10,000 5.7 >10,000
Class IIb HDAC6 >10,000 10.5 >10,000
a

IC50 values were shown as the mean of at least three experiments ± the standard error of the mean.