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. Author manuscript; available in PMC: 2021 Jun 11.
Published in final edited form as: J Med Chem. 2020 May 22;63(11):5865–5878. doi: 10.1021/acs.jmedchem.0c00168

Figure 2.

Figure 2.

(a) and (b) Total mean distance traveled over 15 min. Synthesized compounds were tested at 10 μM and 5 μM, respectively. 5 mM and 10 mM VPA were used as positive controls. Data represents the mean distance traveled, error bar represents SEM, n = 8 for each group. The red color shows > 50% percentage of reduced travel distance (c) Mean distance traveled per 1 min after treatment of 3d and 3l, data are shown as mean distance traveled, error bar represents SEM, n = 8 for each group. With the exception of 3d at 10 μM + PTZ, all time points are significantly different from the positive PTZ run p < 0.01. TW = tank water only control.