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. Author manuscript; available in PMC: 2021 Jun 11.
Published in final edited form as: J Med Chem. 2020 May 22;63(11):5865–5878. doi: 10.1021/acs.jmedchem.0c00168

Table 5.

PK parameters of 2h and 3d.a

Cpd No. Administration Dose (mg/kg) t1/2 (h) tmax (h) Cmax (ng/kg) AUClast (hr*ng/mL)
2h ip 20 1.10 ± 0.08 0.25 1490 ± 79.3 978 ± 111.5
3d ip 20 3.38 ± 0.16 1.00 320 ± 91.7 1716 ± 264.9
a

Note: ip intraperitoneal administration. Three mice were used for each compound.